Semaglutide Technical Specification Sheet
Complete chemical, physical and handling data for semaglutide as supplied — CAS number, molecular formula, sequence, purity, solubility and storage, covering all three vial sizes.
This sheet describes semaglutide as manufactured and supplied. Batch-specific analytical results are reported separately on the Certificate of Analysis issued with each lot. Supplied for laboratory and research use only.
Before working with semaglutide
The semaglutide molecule is an approved medicine in some jurisdictions, but the compound supplied here is an unlicensed research material and is not that medicine. Compounds acting on this receptor pathway have documented gastrointestinal effects, reported signals for pancreatitis and gallbladder complications, and loss of lean mass alongside fat mass. Anyone evaluating this compound in a context involving human health should discuss it with a qualified healthcare professional first.
Semaglutide, developed under the code NN9535, is a 31-amino-acid analogue of the human hormone GLP-1. Two changes to the native sequence and a fatty-acid side chain extend its half-life from roughly two minutes to about a week.
This page is the technical reference — identity, purity, handling and storage. It is a specification, not a research summary. For background on the mechanism and the trial data, see the semaglutide complete guide or the three-way comparison with tirzepatide and retatrutide.
All three vial sizes contain identical material at the same purity specification. Only the quantity differs, which is why one sheet covers the full range.
Product Identification
| Specification | Value |
|---|---|
| Product Name | Semaglutide |
| Product Code | PCR-SEMA-10 through PCR-SEMA-30 |
| Compound Type | Synthetic GLP-1 receptor agonist — fatty-acid-conjugated peptide analogue |
| Synonyms / Other Names | Semaglutide; NN9535; NNC0113-0217 |
| Amino Acid Count | 31 |
| Amino Acid Sequence | H-{Aib}-EGTFTSDVSSYLEGQAA-{Lys(AEEA-AEEA-γGlu-C18 diacid)}-EFIAWLVRGRG-OH |
| Physical Form | Lyophilized powder, single vial |
| Research Category | Metabolic research peptide |
Chemical & Physical Properties
| Specification | Value |
|---|---|
| CAS Number | 910463-68-2 |
| PubChem CID | 56843331 |
| Molecular Formula | C187H291N45O59 |
| Molecular Weight | 4,113.58 g/mol |
| Structural Notes | Modified GLP-1(7-37) backbone with aminoisobutyric acid at position 8 and arginine substituted at position 34; C18 octadecanedioic diacid conjugated at Lys26 through a γ-glutamate spacer and two AEEA units; C-terminal free acid |
| Appearance | White to off-white lyophilized powder |
| Physical State | Lyophilized solid |
| Purity | ≥ 99% by HPLC-MS |
Reading the Sequence Numbering
Semaglutide's structural landmarks are quoted in GLP-1 numbering rather than by position in the delivered chain, and the two do not line up. This trips people up when they try to locate a residue in the sequence.
The lipid-bearing lysine is universally called Lys26, but it is the twentieth residue of the 31-mer. Likewise the aminoisobutyric acid substitution is Aib8 in GLP-1 numbering while sitting at position 2 of the chain, and the Arg34 substitution is at position 28. The offset is six, because native GLP-1(7-37) numbering starts counting at the parent proglucagon residue 7.
C-terminus: acid, not amide
Semaglutide terminates in a free carboxylic acid. Tirzepatide and retatrutide both terminate in an amide. It is a small structural difference that is easy to carry over by mistake when working across all three.
Solubility & Reconstitution
| Specification | Value |
|---|---|
| Solubility | Soluble in bacteriostatic water |
| Recommended Diluent | Bacteriostatic water — supplied complimentary with every peptide order |
| Solution Appearance | May appear slightly turbid; expected for a lipid-conjugated peptide and not a sign of degradation |
| Solution Handling | Prepare fresh, keep cold, and avoid repeated freeze-thaw cycles |
Our vials hold 3 ml, which sets the practical ceiling on how much diluent can be added — the reconstitution calculator works this out for any vial size and target concentration.
Storage & Stability
| Specification | Value |
|---|---|
| Storage — Sealed Vial | Freeze at ≤ −20 °C, sealed, away from light and moisture |
| Shelf Life — Sealed | Approximately 24 months under recommended storage conditions |
| Storage — After Reconstitution | Refrigerate at 2–8 °C |
| In-Use Period | 28–30 days after reconstitution |
| Conditions to Avoid | Heat, direct light, moisture, and repeated freeze-thaw cycles |
Costa Rica's humidity makes storage a live concern rather than a formality. Let a frozen vial reach room temperature fully before breaking the seal, or condensation forms inside it. There is more in storing peptides in tropical climates.
Quality Assurance & Documentation
| Specification | Value |
|---|---|
| Analytical Method | High-performance liquid chromatography with mass spectrometry (HPLC-MS) |
| Batch Testing | Independent third-party analysis for identity, purity, and contaminants |
| Certificate of Analysis | Issued per batch — searchable in the COA database |
| Batch / Lot Number | Printed on the vial label and shown on the accompanying Certificate of Analysis |
The purity figure above is a release specification — the standard every lot must meet before it ships. The measured result for your specific vial is on that lot's Certificate of Analysis.
Intended Use & Regulatory Status
| Specification | Value |
|---|---|
| Intended Use | Research Use Only (RUO) — laboratory, analytical, and scientific applications |
| Uses Advised Against | Not for human or veterinary use. Not a drug, food, cosmetic, dietary supplement, or household product. Not for diagnostic or therapeutic use. |
| Regulatory Status | The semaglutide molecule holds FDA approval as a finished pharmaceutical under Novo Nordisk's brands Ozempic, Wegovy, and Rybelsus. This product is none of those medicines: it is an unlicensed research compound and is not approved for the prevention, diagnosis, treatment, or cure of any disease. |
| Distribution | Supplied within Costa Rica |
Vial Sizes & PDF Downloads
All three sizes are the same material. Each PDF is a print-ready version of this sheet for the specific vial, suitable for filing with research records or attaching to a purchase order.
| Vial Size | Product Code | Product Page | Specification PDF |
|---|---|---|---|
| 10 mg | PCR-SEMA-10 | Semaglutide 10mg | Download PDF |
| 20 mg | PCR-SEMA-20 | Semaglutide 20mg | Download PDF |
| 30 mg | PCR-SEMA-30 | Semaglutide 30mg | Download PDF |
Current pricing and stock across all sizes are on the semaglutide product page. Related compounds sit under peptides for weight loss.
Common Questions
Is semaglutide the same as Ozempic?
Semaglutide is the active molecule in Ozempic, but this product is not Ozempic. Ozempic, Wegovy and Rybelsus are Novo Nordisk's approved medicines, manufactured and released under pharmaceutical quality systems. What we supply is an unlicensed research compound containing the same molecule.
Is the 10 mg vial the same material as the 30 mg?
Yes. Every vial size contains the same peptide at the same ≥99% purity specification, with identical appearance, solubility and storage requirements. Only the quantity in the vial differs.
Why is the lysine called Lys26 when it is the twentieth residue?
Because the literature numbers semaglutide against native GLP-1(7-37), which starts counting at proglucagon residue 7. That puts a consistent offset of six between the published position numbers and the position in the 31-residue chain you actually receive.
How does semaglutide differ structurally from tirzepatide?
Semaglutide is a 31-residue GLP-1 analogue with one aminoisobutyric acid substitution and a C18 diacid chain, ending in a free acid. Tirzepatide is a 39-residue GIP-backbone peptide with two aminoisobutyric acid substitutions and a C20 diacid chain, ending in an amide.
Why does the reconstituted solution look cloudy?
Semaglutide carries a C18 fatty diacid chain, and lipid-conjugated peptides commonly produce a slightly turbid solution. It is expected and is not an indication that the material has degraded.
Is this a Certificate of Analysis?
No. This sheet states the specification every batch must meet. The Certificate of Analysis reports what one specific lot actually measured, with a lot number and test date. If you need to document the exact material you received, you need the COA.
How long does semaglutide last once reconstituted?
Refrigerated at 2–8 °C, 28 to 30 days. Sealed and frozen at ≤ −20 °C, the lyophilized powder holds for approximately 24 months. Repeated freeze-thaw cycles degrade it considerably faster.
Is semaglutide legal in Costa Rica?
The research compound supplied here is sold within Costa Rica for laboratory and research use only, and holds no marketing authorisation from Costa Rica's Ministerio de Salud. We do not ship internationally.
Questions about semaglutide specifications?
If you need a batch certificate, documentation in a specific format for an institutional purchase, or clarification on anything in this sheet, get in touch. We answer every message personally.
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Important disclaimer: The information on this page is general educational and technical content only. It is not medical advice, a prescription, or a personalized recommendation. This specification sheet describes the product as supplied and does not constitute a Certificate of Analysis or a Safety Data Sheet. The semaglutide molecule is approved as a finished pharmaceutical under Novo Nordisk's brands Ozempic, Wegovy, and Rybelsus, all registered trademarks of Novo Nordisk; the compound supplied here is not those medicines, holds no marketing authorisation from the FDA, the EMA, or Costa Rica's Ministerio de Salud, and is intended for laboratory research only. Compounds acting on this receptor pathway carry documented gastrointestinal effects and reported signals for pancreatitis and gallbladder complications, and are associated with loss of lean mass alongside fat mass. Always consult a qualified healthcare professional before beginning any peptide protocol. Products sold by Peptides Costa Rica are intended for laboratory and research purposes only.
