Retatrutide Technical Specification Sheet
Complete chemical, physical and handling data for retatrutide as supplied — CAS number, molecular formula, sequence, purity, solubility and storage, covering all eleven vial sizes.
This sheet describes retatrutide as manufactured and supplied. Batch-specific analytical results are reported separately on the Certificate of Analysis issued with each lot. Supplied for laboratory and research use only.
Before working with retatrutide
Retatrutide is an investigational compound. It has not been approved by any regulatory authority anywhere, and its complete safety profile is not established. Compounds acting on these receptor pathways have documented gastrointestinal effects, reported signals for pancreatitis and gallbladder complications, and loss of lean mass alongside fat mass. Anyone evaluating this compound in a context involving human health should discuss it with a qualified healthcare professional first.
Retatrutide, developed under the code LY3437943, is a 39-amino-acid synthetic peptide that acts on three receptors at once: GIP, GLP-1, and glucagon. That third target is what separates it from the dual agonists that came before it.
This page is the technical reference — identity, purity, handling and storage. It is a specification, not a research summary. For the background on how the compound works and what the trial data shows, see the retatrutide complete guide or the three-way comparison with semaglutide and tirzepatide.
All eleven vial sizes contain identical material at the same purity specification. Only the quantity differs, which is why one sheet covers the full range.
Product Identification
| Specification | Value |
|---|---|
| Product Name | Retatrutide |
| Product Code | PCR-RETA-5 through PCR-RETA-60 |
| Compound Type | Synthetic triple receptor agonist — GLP-1 / GIP / glucagon (GCGR) pathways |
| Synonyms / Other Names | Retatrutide; LY-3437943; LY3437943; GGG tri-agonist |
| Amino Acid Count | 39 |
| Amino Acid Sequence | Y-{Aib}-QGTFTSDYSI-{α-Me-Leu}-LDK-{Lys(AEEA-γGlu-C20 diacid)}-AQ-{Aib}-AFIEYLLEGGPSSGAPPPS-NH2 |
| Physical Form | Lyophilized powder, single vial |
| Research Category | Metabolic research peptide |
| Development Status | Investigational — under clinical study, not an approved product |
Chemical & Physical Properties
| Specification | Value |
|---|---|
| CAS Number | 2381089-83-2 |
| Molecular Formula | C221H342N46O68 (free peptide) |
| Molecular Weight | 4,731.33 g/mol (free peptide) |
| Structural Notes | GIP peptide backbone incorporating three non-coded residues (Aib2, αMeL13, Aib20); C20 fatty diacid conjugated via a linker at Lys17 |
| Appearance | White to off-white lyophilized powder |
| Physical State | Lyophilized solid |
| Purity | ≥ 99% by HPLC-MS |
Reading the Formula Correctly
Retatrutide's molecular formula is widely misquoted, including on supplier documentation, so it is worth being precise about which number applies to what.
The free peptide is C221H342N46O68 at 4,731.33 g/mol. That is the figure in the table above, and it is the one to use for molar calculations unless your Certificate of Analysis says otherwise.
Synthetic peptides purified by reverse-phase chromatography are frequently isolated as a trifluoroacetate salt. Where that applies, the formula picks up an extra C2HF3O2 and the mass rises accordingly. A formula containing fluorine paired with the free-peptide molecular weight is a mismatch — one of those two numbers describes a different species.
Peptide content vs gross weight
Where a peptide is supplied as a salt, the vial's gross weight includes counter-ion and residual moisture. If your work depends on exact peptide content rather than nominal vial weight, the Certificate of Analysis for your lot is the document that settles it.
Solubility & Reconstitution
| Specification | Value |
|---|---|
| Solubility | Approximately 20 mg/mL in water; approximately 50 mg/mL in DMSO (10.57 mM) |
| Recommended Diluent | Bacteriostatic water — supplied complimentary with every peptide order |
| Solution Appearance | May appear slightly turbid; expected for a lipid-conjugated peptide and not a sign of degradation |
| Solution Handling | Prepare fresh, keep cold, and avoid repeated freeze-thaw cycles |
Our vials hold 3 ml, which sets the practical ceiling on how much diluent can be added — the reconstitution calculator works this out for any vial size and target concentration.
Storage & Stability
| Specification | Value |
|---|---|
| Storage — Sealed Vial | Freeze at ≤ −20 °C, sealed, away from light and moisture |
| Shelf Life — Sealed | Approximately 24 months under recommended storage conditions |
| Storage — After Reconstitution | Refrigerate at 2–8 °C |
| In-Use Period | 28–30 days after reconstitution |
| Conditions to Avoid | Heat, direct light, moisture, and repeated freeze-thaw cycles |
Costa Rica's humidity makes storage a live concern rather than a formality. Let a frozen vial reach room temperature fully before breaking the seal, or condensation forms inside it. There is more in storing peptides in tropical climates.
Quality Assurance & Documentation
| Specification | Value |
|---|---|
| Analytical Method | High-performance liquid chromatography with mass spectrometry (HPLC-MS) |
| Batch Testing | Independent third-party analysis for identity, purity, and contaminants |
| Certificate of Analysis | Issued per batch — searchable in the COA database |
| Batch / Lot Number | Printed on the vial label and shown on the accompanying Certificate of Analysis |
The purity figure above is a release specification — the standard every lot must meet before it ships. The measured result for your specific vial is on that lot's Certificate of Analysis.
Intended Use & Regulatory Status
| Specification | Value |
|---|---|
| Intended Use | Research Use Only (RUO) — laboratory, analytical, and scientific applications |
| Uses Advised Against | Not for human or veterinary use. Not a drug, food, cosmetic, dietary supplement, or household product. Not for diagnostic or therapeutic use. |
| Regulatory Status | Investigational. Not approved or licensed by the U.S. FDA, the EMA, or Costa Rica's Ministerio de Salud for the prevention, diagnosis, treatment, or cure of any disease. |
| Distribution | Supplied within Costa Rica |
Vial Sizes & PDF Downloads
All eleven sizes are the same material. Each PDF is a print-ready version of this sheet for the specific vial, suitable for filing with research records or attaching to a purchase order.
| Vial Size | Product Code | Product Page | Specification PDF |
|---|---|---|---|
| 5 mg | PCR-RETA-5 | Retatrutide 5mg | Download PDF |
| 10 mg | PCR-RETA-10 | Retatrutide 10mg | Download PDF |
| 12 mg | PCR-RETA-12 | Retatrutide 12mg | Download PDF |
| 15 mg | PCR-RETA-15 | Retatrutide 15mg | Download PDF |
| 20 mg | PCR-RETA-20 | Retatrutide 20mg | Download PDF |
| 24 mg | PCR-RETA-24 | Retatrutide 24mg | Download PDF |
| 25 mg | PCR-RETA-25 | Retatrutide 25mg | Download PDF |
| 30 mg | PCR-RETA-30 | Retatrutide 30mg | Download PDF |
| 40 mg | PCR-RETA-40 | Retatrutide 40mg | Download PDF |
| 50 mg | PCR-RETA-50 | Retatrutide 50mg | Download PDF |
| 60 mg | PCR-RETA-60 | Retatrutide 60mg | Download PDF |
Current pricing and stock across all sizes are on the retatrutide product page. Related compounds sit under peptides for weight loss.
Common Questions
Is the 5 mg vial the same material as the 60 mg?
Yes. Every vial size contains the same peptide at the same ≥99% purity specification, with identical appearance, solubility and storage requirements. Only the quantity in the vial differs.
Which molecular formula is correct for retatrutide?
C221H342N46O68, at 4,731.33 g/mol, for the free peptide. Formulas containing fluorine describe the trifluoroacetate salt, which has a higher mass. Pairing a fluorine-containing formula with the free-peptide weight is a common error in circulating documentation.
How many amino acids does retatrutide have?
39. Three of them are non-coded residues — two aminoisobutyric acid substitutions and one α-methyl-leucine — which is what gives the peptide its resistance to enzymatic breakdown.
Why does the reconstituted solution look cloudy?
Retatrutide carries a C20 fatty diacid chain, and lipid-conjugated peptides commonly produce a slightly turbid solution. It is expected and is not an indication that the material has degraded.
Is retatrutide approved anywhere?
No. It remains an investigational compound in clinical development and holds no approval from the FDA, the EMA, or Costa Rica's Ministerio de Salud. It is supplied here for laboratory and research use only.
Is this a Certificate of Analysis?
No. This sheet states the specification every batch must meet. The Certificate of Analysis reports what one specific lot actually measured, with a lot number and test date. If you need to document the exact material you received, you need the COA.
How long does retatrutide last once reconstituted?
Refrigerated at 2–8 °C, 28 to 30 days. Sealed and frozen at ≤ −20 °C, the lyophilized powder holds for approximately 24 months. Repeated freeze-thaw cycles degrade it considerably faster.
Is retatrutide legal in Costa Rica?
It is supplied within Costa Rica for laboratory and research use only. It is not approved as a pharmaceutical product for human use by any regulatory authority. We do not ship internationally.
Questions about retatrutide specifications?
If you need a batch certificate, documentation in a specific format for an institutional purchase, or clarification on anything in this sheet, get in touch. We answer every message personally.
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Important disclaimer: The information on this page is general educational and technical content only. It is not medical advice, a prescription, or a personalized recommendation. This specification sheet describes the product as supplied and does not constitute a Certificate of Analysis or a Safety Data Sheet. Retatrutide is an investigational compound and is not approved or licensed by the U.S. FDA, the EMA, or Costa Rica's Ministerio de Salud for any use; its long-term safety profile in humans is not established. Compounds acting on these receptor pathways carry documented gastrointestinal effects and reported signals for pancreatitis and gallbladder complications, and are associated with loss of lean mass alongside fat mass. Always consult a qualified healthcare professional before beginning any peptide protocol. Products sold by Peptides Costa Rica are intended for laboratory and research purposes only.
